Betacoronavirus – Communicable Diseases Research

In silico and in vitro evaluation of imatinib as an inhibitor for SARS-CoV-2

Article

Published on 2023-04-012023-07-08
Journal: Journal of biomolecular structure & dynamics
[Category] COVID19(2023년),

Porcine Hemagglutinating Encephalomyelitis Virus Co-Opts Multivesicular-Derived Exosomes for Transmission

Article

Published on 2023-02-282023-07-11
Journal: mBio
[Category] COVID19(2023년),

[키워드] Betacoronavirus Exosome innate response porcine hemagglutinating encephalomyelitis virus Transmission.
[DOI] 10.1128/mbio.03054-22 PMC 바로가기

Repertoires of SARS-CoV-2 epitopes targeted by antibodies vary according to severity of COVID-19

코로나19 중증도에 따라 항체 표적 SARS-CoV-2 에피토프 레퍼토리 달라

Article

Published on 2022-12-012022-09-11
Journal: Virulence
[Category] COVID19(2023년), SARS, 진단, 치료법,

[키워드] antibodies antibody Antigen association Asymptomatic asymptomatic individual asymptomatic infection Betacoronavirus betacoronavirus Community convalescent correlated COVID-19 COVID-19 severity develop diagnosed diagnostics disease severity domains Epitopes Evidence evidence of finding FIVE five groups HKU1 Hospitalization IgG IgGs Immunity immunogenic immunogenic peptide individual Infection less MERS-CoV nucleocapsid protein Nucleocapsid proteins OC43 participant pathogenic pathogenic mechanisms peptide peptide array peptides pilot study predicted Protein RBDs reaction Receptor binding domain Region repertoire SARS-CoV RBD SARS-CoV RBDs SARS-CoV-2 SARS-CoV-2 epitope SARS-CoV-2 epitopes seroconverted Seroprevalence seroprevalence. severity severity of COVID-19 symptomatic symptomatic COVID-19 symptomatic infection therapeutic therapeutic antibodies Vaccines Viral with COVID-19 without symptoms
[DOI] 10.1080/21505594.2022.2073025 PMC 바로가기 [Article Type] Article

Seasonality of Common Human Coronaviruses, United States, 2014-20211

Article

Published on 2022-10-012022-11-15
Journal: Emerging Infectious Diseases
[Category] 치료기술,

Mapping monoclonal anti-SARS-CoV-2 antibody repertoires against diverse coronavirus antigens

Article

Published on 2022-09-022022-11-15
Journal: Frontiers in Immunology
[Category] SARS, 변종, 진단,

Covid-19, an unfinished story

Mini review

Published on 2022-09-012022-10-05
Journal: La Presse Médicale
[Category] COVID19(2023년), SARS, 변종, 치료제,

[키워드] activities acute respiratory distress age amplitude bat coronavirus Beta Betacoronavirus caused China Cluster Comorbidities compulsory vaccination condition confirmed case coronavirus COVID-19 Critical cross deaths degree Delta detect development drug effective Efficacy epidemic waves epidemiological surveillance evade Face mask FIVE form Gamma Genome genomic Health highly pathogenic homogeneity Host Human immune response Immunity incidence rate include Inflammatory Innovation intensive care Measures Messenger RNA mild infection Moderna mRNA vaccine multiorgan failure nucleotides occupancy rate omicron Oxygen therapy pandemic Patient Pfizer-BioNTech Pneumonia preventing the transmission progressed Protective replaced RNA SARS-CoV-2 SARS-CoV-2 vaccine Sequencing severity syndrome the WHO thromboembolic complications Vaccine Vaccines variant variants variants of concern viral invasion VoC WHO World Health Organization
[DOI] 10.1016/j.lpm.2022.104131 [Article Type] Mini review

ORF8 protein of SARS-CoV-2 reduces male fertility in mice

SARS-CoV-2의 ORF8 단백질은 쥐의 수컷 생식력을 감소시킵니다

Article

Published on 2022-09-012022-09-11
Journal: Journal of medical virology
[Category] COVID19(2023년), MERS, SARS, 진단, 치료기술,

[키워드] abnormality accompanied acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Administered Analysis Antibody titer Antibody titers Betacoronavirus body weight can be used circulating Col1a1 convalescent patient coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 cultured cells decreased expression dependent on Endoplasmic reticulum examined Food Intake Gene Expression genus genus Betacoronavirus Human in vivo indicated Infection infertility inhibited inhibitor injection male mice Morphological N-terminal observation Open reading frame open reading frames ORF8 ORF8 protein oxygen peptide peptide sequence plasma sample plasma samples Protein provide reactive oxygen specy reduce reproductive reproductive system respiratory SARS-CoV-2 secretion secretion. sequence severe acute respiratory syndrome Coronavirus signal peptide testes the patient translated vitality
[DOI] 10.1002/jmv.27855 PMC 바로가기 [Article Type] Article

SARS-CoV-2 ORF6 disrupts innate immune signalling by inhibiting cellular mRNA export

Article

Published on 2022-08-252022-11-15
Journal: PLoS Pathogens
[Category] SARS, 유전자 메커니즘, 치료제,

Translational feasibility and efficacy of nasal photodynamic disinfection of SARS-CoV-2

SARS-CoV-2의 비강 광역학 소독의 번역 타당성 및 효능

Clinical Trial

Published on 2022-08-242022-09-11
Journal: Scientific Reports
[Category] SARS, 변종, 임상, 치료법,

[키워드] Antiviral treatment Bacterial Betacoronavirus clinical trial contributed COVID-19 dependent on early stage early stages Effect effective Effective vaccines Efficacy feasibility global pandemic human betacoronavirus in vitro in vitro result in vitro results inactivation Infection investigated lack Local Methylene Methylene blue nare nares nasal not dependent OC43 Pathogens Perspective photodynamic therapy practicality principle qPCR Quantitative reduce RNA RT-qPCR Safe SARS-CoV-2 SARS-CoV-2 viral load Swab therapeutic option therapeutic options therapy undetectable variants variety viral infectivity viral pathogen viral pathogens Viral RNA virus was reduced
[DOI] 10.1038/s41598-022-18513-0 PMC 바로가기 [Article Type] Clinical Trial

Exploring the Immunomodulatory Aspect of Mesenchymal Stem Cells for Treatment of Severe Coronavirus Disease 19

중증 코로나바이러스 질환 치료를 위한 중간엽 줄기세포의 면역조절 측면 탐색 19

Review

Published on 2022-07-122022-09-11
Journal: Cells
[Category] COVID19(2023년), SARS, 치료법,

[키워드] ACE-2 acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 acute respiratory syndrome coronavirus-2 administration affected Alpha alveolar epithelial cell alveolar epithelial cells angiotensin angiotensin converting enzyme angiotensin converting enzyme 2 anti-apoptotic Anti-inflammatory anti-oxidative aspect Asymptomatic average Betacoronavirus breathlessness cause cellular characterized chemokines chest pain Clinical outcome Clinical symptoms colony-stimulating factor coronavirus 2 COVID-19 COVID-19 patient Critically ill critically ill COVID-19 patients curative cytokine Cytokine storm Cytokine storms damaged dependent on Deterioration disease severity dry cough Effectiveness Effects elicited endothelial engage enzyme epithelial cells excessive inflammation family Coronaviridae fatigue Fever fibroblast fibroblast growth factor functional GCSF genus genus Betacoronavirus granulocyte granulocyte colony-stimulating factor growth factor Growth factors Health healthy histological IL-6 IL-7 IL-8 IL-9 immune cells immune response immune responses immunomodulation immunomodulatory immunomodulatory capabilities immunomodulatory capability Incubation period individual infected individual infected individuals infiltrating immune cells Inflammatory Inflammatory cytokines inflammatory protein inhalation Injury Intention interferon interleukin intravenous intravenous infusion Invasion IP10 lung Lungs Macrophage majority MCP1 Mesenchymal stem cells mesenchymal stem cells. MIP1A mitigate monocyte monocyte chemotactic protein-1 MSC MSCs multitude myriad Necrosis organ PDGFB persistence Platelet platelet-derived growth factor positioned positive Protein receptor reduce respiratory Respiratory droplets RNA SARS-CoV-2 SARS-COV-2 infection secretion Secretome Severe acute respiratory syndrome severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus-2 sore throat STEM stem cell stem cells subunit supportive therapy symptomatic therapeutic therapy tissue TNF-α translational transmitted Treatment Tumor tumor necrosis tumor necrosis factor tumor necrosis factor alpha undergo Vascular virus widespread
[DOI] 10.3390/cells11142175 PMC 바로가기 [Article Type] Review